Type: Nandrolone decanoate injection solution 5/200 mg / ml
Synthetic derivative of testosterone with low androgenic, but enhanced anabolic effect.
Anabolic effect is the activation of reparative processes in the epithelium (coverslip and glandular), bone and muscle tissue by stimulating protein synthesis and structural components of cells. Increases the completeness of absorption of amino acids from the small intestine (in the background diet rich in protein), creating a positive nitrogen balance.
Stimulates the production of erythropoietin and activates anabolic processes in the bone marrow, while the appointment of iron appears antianemic action. Inhibits the synthesis of endogenous gonadotropins and testosterone. In high doses, inhibits spermatogenesis. Can delay growth and sexual development of children.
Violates the synthesis of vitamin K-dependent plasma coagulation factors (II, VII, IX, X) in the liver, plasma lipid profile changes (increases and decreases the concentration of LDL cholesterol content), increases the reabsorption of sodium and water in the kidneys, contributing to the formation of edema. These effects disappear after discontinuation.
After a / m 100 mg Cmax created in 1-3 weeks. Biotransformation in the liver with the formation of 17-ketosteroids. Displayed in the urine (90%) and about 6% – in the feces.
Treatment of anemia in renal failure (increased hemoglobin and cell mass), diabetic retinopathy, myodystrophy, spinal amyotrophy Werding-Hoffmann, breast cancer (adjuvant), glomerulonephritis, extensive burns, osteoporosis.
DOSAGE AND ADMINISTRATION
V / m deep.
with anemia (iron supplements at the same time) – 100-200 mg (women – 50-100 mg), 1 per week to stimulate anabolic processes – 50-200 mg (women – 50-100 mg) 1 every 1-4 weeks for children 2-13 years old – 0.4 mg / kg 1 every 3-4 weeks. The duration of the course (at 1-4-week interval between injections) – up to 12 weeks, a second course – 8 weeks after the last injection. Treatment is carried out on the background of the high-protein diet.
The women – virilization symptoms, inhibition of ovarian function, menstrual cycle, hypercalcemia.
Men: prepuberal – symptoms of virilization, idiopathic hyperpigmentation of the skin, slowing or cessation of growth (calcification of epiphyseal growth zones of long bones) in post-pubertal – bladder irritation, gynecomastia, priapism, and in old age – hypertrophy and / or carcinoma of the prostate .
Men and women – the progression of atherosclerosis, peripheral edema, dyspeptic disorders, hepatic dysfunction with jaundice, changes in leucocyte count, pain in the long bones, anticoagulation with a tendency to bleeding.
Hypersensitivity to the drug, prostate cancer, breast cancer in men, breast carcinoma in women with hypercalcemia, CHD, marked atherosclerosis, nephrotic syndrome, acute and chronic liver disease, including alcoholic destruction, nephritis, pregnancy, breast-feeding.
SAFETY FEATURES AND APPLICATIONS
When the first signs of virilization in women (coarsening voice, hirsutism, acne, klitoromegaliya) should be discontinued to prevent irreversible changes.
There may come a suppression of factors II, VII, IX and X of blood coagulation and prothrombin time. Periodically check the level of lipidemia and hypercholesterolemia.
The drug should be administered to children experienced to avoid premature epiphyseal ossification of the bones.
Interactions with other drugs
Glucocorticoids, mineralocorticoids, corticotropin natriysoderzha-ing drugs and foods rich in sodium, potentiate the retention in the body, increasing the risk of edema, increase the severity of acne.
Enhances the effects of antiplatelet agents, indirect anticoagulants, insulin and oral antidiabetic agents weakens – STG and its derivatives.